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muhdohub

Timeless

Timeless 1 month supply / £2.26 per day

“Whilst getting older is inevitable. Feeling older is not”

Timeless unlocks Healthy Ageing with 45 essential vitamins, minerals and other special ingredients and co-factors scientifically designed with the latest in Epigenetic Science.

Start your Longevity Journey
Nourish your Genes
Enhanced Cell Absorption
Improve DNA Methylation

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Key Benefits

✅ DNA Methylation Support
✅ Mitochondrial Health
✅ Glutathione Production
‍
Transform your health at the Genetic level with Timeless, which supports key longevity pathways such as DNA Methylation, Mitochondrial Health and Glutathione Production.

To enable DNA Methylation to occur efficiently the body requires key nutrients and cofactors, which are the foundations of Timeless, such as B Vitamins (B12 and Folate) and Methyl donors such as SAMe (S-adenosylmethionine).
‍
To enable DNA Methylation to occur efficiently the body requires key nutrients and cofactors, which are the foundations of Timeless, such as B Vitamins (B12 and Folate) and Methyl donors such as SAMe (S-adenosylmethionine).

Timeless has also provided a whole variety of special ingredients to support various longevity pathways such PQQ (Pyrroloquinoline quinone) to enhance your Mitochondrial Health.

This is crucial to longevity, as the mitochondria are the powerhouses of your cells, generating the energy required for vital processes, regulating cellular metabolism, and controlling apoptosis (programmed cell death)Their dysfunction accelerates ageing, promotes chronic diseases, and diminishes overall resilience to stress and injury.
‍
Glutathione is one of the body’s most powerful antioxidants, playing a crucial role in protecting cells from oxidative stress and supporting detoxification. It's produced naturally in the liver from three amino acids: cysteine, glutamine, and glycine.

Nutrients like N-Acetyl-L-Cysteine (NAC), Glycine and Selenium are key in boosting glutathione production and recycling it in the body.

Maintaining healthy glutathione levels is essential for immune function, mitochondrial health, and neutralising free radicals that can damage cells over time.

A deficiency in any of these critical elements can disrupt proper gene regulation and antioxidant capacity potentially leading to issues like Premature Ageing, Inflammation, or an increased risk of Chronic diseases.

Ingredients

Longevity Genes and Pathways

DNA Methylation
Function: DNA methylation is a crucial epigenetic process that regulates gene expression, ensuring that genes are turned on or off at the right times. This process plays a key role in ageing, cellular repair, detoxification, and overall health.

FOXO1 and FOXO3
Function: Regulates oxidative stress resistance, apoptosis and known as one of the main “Longevity Genes”. It’s associated with extended lifespan and has a protective effect against age-related diseases.
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SIRT1 and SIRT6 (Sirtuins)
Function: Sirtuins are a family of Genes associated with extending lifespan and metabolic health. They’re involved in DNA Repair, Inflammation regulation and crucial for your Longevity.

P53
Function: Is a powerful tumour suppressor gene that’s also strongly associated to Cellular Repair and Senescence.

mTOR Pathway
Function: Is heavily involved in regulating Ageing and Cellular Metabolism.
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Certain nutrients such as SAMe helps regulate mTOR activity, promoting autophagy and reducing cellular damage, which are hallmarks of improved Longevity.

AMPK Pathway
Function: Is a key regulator of Mitochondrial Health, Oxidative Stress and the Cellular Recycling process (Autophagy).

GPX and Glutathione
Function: The GPX (Glutathione Peroxidase) genes play a critical role in protecting your cells from oxidative stress. They work by supporting the activity of glutathione, one of the body’s most powerful antioxidants.

Mitochondrial Health
Function: Mitochondria are the powerhouses of your cells, responsible for producing the energy your body needs to function. Healthy mitochondria are essential for energy metabolism, cellular repair, and reducing oxidative stress.

Our clients say about us...

29 Aug 24

The Data is amazing

The data is amazing, I only wished I had done this earlier. The analytics have shown that some supplements that I was taking were actually of no benefit this saving money and can focus in on what my body actually needs. Amazing

D V

2 May 2024

Muhdo keeps coming up tops

Muhdo keeps coming up tops in every area... certain the leaders.

They're very serious about providing accurate scientifically-backed data in an excellent App... you can confidently apply this to your life easily.
There is an abundance of in-depth information on every DNA and Epigenetic result (and more), for novices and experts alike.
They were the first to make Epigenetic tests widely available... that's a bold and giant step forward... it means they were the original innovators with a true focus on positively impacting your life. They continue to innovate ahead of the curve.
Choose Muhdo... the expert choice.

Wayne kmaminsky

1 May 2024

I purchased the DNA test kit to see my...

I purchased the DNA test kit to see my genetics and how my body functions. The eye opener for me was seeing that I have a fast metabolism but my body doesn’t absorbs saturated fats very well. When I reduced saturated fats and started eating a higher protein intake because my body has a good response to protein I started to loose weight quickly alongside an exercise plan. It’s really good to also see vitamins deficiency and to change the way you fuel your body. I would highly recommend purchasing one of these kits to start to understand your body and to help you support your body.

Tom Piggot

muhdohub

DNA or Epigenetic Tests

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DNA Test (Free with Timeless Subscription)

Take your first step into the world of DNA discovery. Uncover what makes you unique and the genetic truth about your body.

The Core DNA Test provides you with the building blocks to a healthier life with results focused on diet, vitamins, stress, and another 40+ general health concerns.

A simple saliva sample is analysed by our custom technology with our Core DNA test, and with the ability to unlock an additional 140+ New genetic health areas.

Each additional area focuses on a specific topic to provide results and recommendations according to your health goal or interest, allowing you to unlock your DNA’s potential, and start your journey for a healthier you.

DNA + Epigenetics Test

Take the next step and “Go beyond your DNA” with the latest in longevity science and the fascinating world of Epigenetics.

Our Epigenetic test provides valuable insight into how your lifestyle and environment are influencing your health at a genetic level. Unlike traditional DNA tests that reveal fixed traits, epigenetic testing looks at chemical markers that can turn genes on or off.

These markers can change over time based on factors like diet, stress, exercise, sleep, exposure to toxins, and other environmental influences.

Epigenetics allows you to track to see how your day-to-day life is affecting your genes!?

Our DNA + Epigenetics Test provides you with all the key benefits from our Core DNA Test, but then through the new and exciting world of Epigenetics, allows you to discover your biological age and “True real time methylation patterns” to understand the effects of cellular ageing.

Epigenetics Retest

The Epigenetics Retest allows you to track the progression of your gene methylation, biological age, and overall cellular health over the last 3, 6, or 12 months after your Initial Epigenetics Test.

muhdohub

Vitamins & Minerals

"A new GENEration for longevity"

The muhdohub Core Range is the ideal complement to your Timeless subscription, giving your routine an extra boost. Alternatively, you can purchase individual supplements tailored to your specific health needs.

Vitamins and minerals are essential nutrients that serve as the foundation for human health. They play critical roles in almost every biological process, from energy production and Immune Function to Cellular Repair and DNA Synthesis.

Whilst certain compounds currently being promoted as “Miracle’ supplements, such as NMN, have gained attention for their potential to enhance Cellular energy and contribute to the overall well-being, they appear to exhibit effects by only addressing specific pathways.

In contrast, vitamin and mineral deficiencies affect a broader range of critical functions, ensuring the/their effect on health and longevity are far more significant.

"Longevity begins with the nutrients you’ve forgotten”

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Tri-Magnesium

_{Reduce Stress/Improve Sleep
‍}‍
‍Did you know?
Magnesium supports numerous aspects of health, including:
‍
‍✅ Promoting Muscle and Nerve Function
✅ Reducing Stress and Anxiety
✅ Improving Sleep Quality
✅ Supporting Heart Health
✅ Helps maintain Healthy Blood Pressure Levels

Tri-Magnesium is the perfect blend of three types of Magnesium (Glycinate, Citrate, Malate), all extremely important variations of the mineral and cofactors which are responsible for over 300 forms of enzymatic reactions in your body.

Magnesium Glycinate has excellent bioavailability and is uniquely bound to Glycine, an Amino Acid which has numerous health benefits.

Magnesium Citrate is connected to citric acid which again has a high bioavailability and provides muscle, cardiovascular and metabolic support.

‍Magnesium Malate is derived from Malic Acid which is naturally occurring and found in fruit. It helps to enhance detoxification as it binds heavy metals such as aluminum and eliminates them from the body.

Excellent Bioavailability
Improve 100's of Enzymatic reactions
Energy Production
Stress Sleep Aid

Longevity Hallmarks and Pathways Influenced by Magnesium

Magnesium plays a pivotal role in several hallmarks of ageing and longevity pathways.

Mitochondrial Health: Magnesium is essential for mitochondrial ATP production, and malic acid further contributes by participating in the citric acid cycle. Enhanced mitochondrial function reduces oxidative stress, a key driver of cellular ageing.

Epigenetic Regulation: Magnesium is a co factor for enzymes like DNA methyltransferases, which modulate gene expression through epigenetic mechanisms.

Proper magnesium levels can influence cellular programming and resilience against age-related diseases.

What have muhdohub seen so far?

magnesium as Glycinate, Citrate and others (N = 380)

46.3 years was the average chronological age of Magnesium users.
44.1 years was the average biological age (2.2 years younger) as measured by our Epigenetic clock (methylpace)
60% of Magnesium users sleep 6-8 hours per night.

Magnesium supplementation affects the genes SLC9A1, IGF2 and mTOR

helping with regulation are part of multiple epigenetic algorithms such as the Muhdo's Inflammation, Methylpace and Memory Age.

Tri- Magnesium 1 month supply/120 capsules provide a combined 450mg of multiple forms of magnesium which ensures support for DNA health, cellular repair and energy production.

‍

Vitamin D3

Enhance Immune and Brain Function

_{Plus (k2 (MK7), Boron, Magnesium Taurate, Sulforaphane)}

‍Did you know?

Vitamin D3 is essential for maintaining overall health and well-being.

✅ Supporting Strong Bones

✅ Strengthens the Immune System

✅ Contributes to Mood Regulation

✅ Reduced Risk of Depression

✅ Improved Cardiovascular Health

‍

muhdohub Vitamin D3 is a world’s first and genetically designed to help regulate 100’s of genes and Longevity pathways in your body.

Activates key genes FOXO3 and SIRT1 to support Longevity.
Supports BDNF, promoting Brain Function and Mental health.
Regulates VDR gene activity to Enhance Immunity.
Supports Heart Health by influencing Inflammatory Pathways.

muhdohub Vitamin D3 also provides additional key nutrients and essential co-factors such as Vitamin K2, Magnesium, Boron & Sulforaphane to enhance the absorption, activation and bioavailability of Vitamin D.

Enhancing Vitamin D Receptor Expression

Research indicates that sulforaphane's ability to upregulate Nrf2 can also lead to increased expression of the VDR, thereby improving a cell's capacity to use vitamin D effectively.

Sulforaphane helps maintain the activity of Vitamin D activating enzymes while reducing excessive expression of CYP24A1, preserving more active vitamin D in circulation.

DNA Nutrient Inefficiency

A DNA nutrient inefficiency is a genetic predisposition that affects how your body metabolise, absorbs, or utilises specific nutrients such as vitamin D.

It does not measure nutrient levels at that present time, but highlights inherited traits that may make it harder to obtain health from your diet and/or a supplement, which might lead to inefficiencies or increased nutrient requirements.

What have muhdohub seen so far?

Vitamin D3 (N=1780)

46.2 years was the average chronological age of vitamin D3 users.
42.1 years was the average biological age, as measured by our Epigenetic clock (methylpace), so a nice reduction.
90.7% of uses who take Vitamin D3 state subjectively they are in either great or excellent health.
80% of users who take Vitamin D3 state they sleep for 7-9 hours per night.

muhdohub D3 provides 1 months' supply housed in a Patented Sustained Release dosage format - Liquid/Capsule Combi Soft gel for Protection

Each providing

Precision Dosage
One Capsule Multiple Ingredients
Gentle on your stomach
Fast Acting & Efficient

Omega 3

_{Healthy Inflammation and Ageing}

Did you know?
Omega-3 fatty acids offer a wide range of health benefits, playing a vital role in heart, brain, and overall cellular health.
‍
✅ Support Cardiovascular Health
✅ Lowering Blood Pressure
✅ Anti-Inflammatory Properties
✅ Cognitive Function and Mood Regulation
✅ Supports Eye and Skin Health

Omega 3 provides the 2000mg’s of the highest quality (EPA) and (DHA) which help to reduce the activation of NF-κB, a Gene and Key Pathway regulating inflammation, often linked to ageing and age-related diseases.

Omega 3 fatty acids promote Autophagy, the process by which cells break down and recycle damaged components and creating new and healthier cells.

The EPA and DHA in Omega 3 Influence inflammation and Longevity genes by:

Producing molecules that resolve Inflammation.
Suppressing inflammatory pathways like NF-kB.
Improves Mitochondrial Function.
Activating gene expression through SIRT1 and Epigenetic changes.
Protecting telomeres from shortening, a key factor in Healthy Ageing.

What muhdohub have seen so far?

Omega 3 (N=13)

43.2 years was the average chronological age of vitamin Omega 3 users.
39.2 years was the average biological age as measured by our Epigenetic clock (Methylpace)

Omega-3 has a significant effect on multiple genes that are in the methylpace bio age algorithm, it appears to aid in stabilising ELOVL2, LHFPL4 and PRLHR.

Omega 3 Fish Oils are housed in patented delayed soft release soft gels.

‍Enterisoft- 1step utilizes Alginate, a material from Seaweed to produce a perfectly clear, one step process, delayed release Soft Gel.

The benefits of Enterisoft-1 step Soft Gels:

No Fishy Burps
No Taste or after Taste
No Reflux
No Degeneration of Actives at Low pH
Better Shell Barrier Properties

B-Vitamin Complex

Energy production and DNA Health

Did you know?

B Vitamins provide a wide range of health benefits by supporting energy production, brain function, and overall metabolic health.

✅ Help to Reduce Fatigue

✅ Healthy Nervous System

✅ Supporting Mood Balance

✅ Reduce Stress and Anxiety

✅ Healthy Skin, Hair and Nails

B- Vitamin Complex is a comprehensive and distinctive blend of nine essential B Vitamins combined with Betaine (TMG) and Choline GPC to improve DNA Methylation, Gene Function and overall Cellular Health.

Reduce High Homocysteine Levels.
Balanced Gene Expression and Genomic Stability.
Supports Healthy Methylation and Gene Health.

B-Complex is not your standard B Vitamin supplement. It offers you a 1-month supply/60 capsules with a precisely designed blend of 11 key nutrients to improve your DNA methylation, Genetic Health and Function.

Betaine (TMG) is an innovative and in many ways a superior nutrient which supports healthy Gene Methylation and function by reducing a potentially harmful amino acid called Homocysteine.

Choline GPC is another distinct and vital nutrient which supports your Gene Health, DNA Methylation and overall balanced gene expression and genomic stability.

What have muhdohub seen so far?

B12 (N=231)

45.9 years was the average chronological age of vitamin B12 users.
44.1 years was the average biological age as measured by our Epigenetic clock (methylpace).
82% of B12 users had good /fantastic scores on the Muhdo overall inflammation score.
89.1% of B12 users subjectively claim they are in either great or excellent health.

Selenium +

Antioxidant and Thyroid Health

_{(Iodine, Vitamin C & Magnesium Citrate)}

Did you know?

Selenium is an essential trace mineral and powerful antioxidant that plays a vital role in supporting overall health and well-being.

✅ Protect Cells from Oxidative Stress

✅ Healthy Immune System

✅ Supports Thyroid Function

✅ Cognitive Health

✅ Strong Antimicrobial

Selenium+ harnesses the vital health benefits of Selenium, a trace mineral often lacking in our daily diets.

Gene GPX1 (Glutathione Peroxidase) ability to combat Oxidative Stress, Cellular Damage and influence Ageing is dependent on an individual’s Selenium levels.

Selenium + provides 1 months’ supply/60 capsules with the necessary cofactors in Magnesium, Vitamin C and Iodine to enhance and maximise the bioavailability and benefits that Selenium delivers.

Increases gene GPX1 (Glutathione)
Combat Oxidative Stress
Improve Thyroid Function
Cellular Antioxidant Pathway

Thyroid Regulation and Metabolic Health

Selenium dependent deiodinases ensure the efficient conversion of thyroid hormones to active or inactive forms, thereby fine-tuning metabolic rate. A well-regulated metabolism is obviously crucial for healthy weight management, and energy levels.

Iodine and Selenium: A Synergistic Relationship

Iodine and selenium are two essential trace elements that play critical roles in thyroid function, metabolism, and overall cellular health.

Iodine indirectly improves selenium function by improving thyroid hormone metabolism and supporting the physiological pathways where selenium-dependent proteins (selenoproteins) are active.

Vitamin C and Selenium

Vitamin C and selenium work together to support immune function, antioxidant defence, and cellular health. Vitamin C enhances selenium absorption and optimises its function in the body by improving the bioavailability of selenium and protecting it from oxidative degradation.

Magnesium and Selenium Function

Magnesium is required for the function of enzymes that process selenium-containing compounds into bioactive forms. These include enzymes involved in the synthesis of selenoproteins, which rely on magnesium dependent processes such as ATP generation.

How subscriptions work in three easy steps

1. Choose Supplement

Select your ideal supplement tailored to your goals and genetic profile. From energy to recovery, find your perfect match for optimal wellness.

2. Pick Frequency

Set your delivery frequency to match your lifestyle. Choose from monthly, bi-monthly, or quarterly options for your convenience and flexibility.

3. Revitalize

Experience enhanced vitality and well-being as our personalized supplements support your body’s natural functions and health optimization.

Three simple steps to start your DNA Health Journey

Step 1: Subscribe to Timeless and claim your free DNA kit

Join Timeless today and unlock your exclusive DNA kit at no extra cost. Start your journey to better health with a simple subscription!

Core DNA Test
‍
Unlocks the building blocks to a healthier life with results focused on diet, vitamins, stress, and another 40+ general health concerns and with the ability to unlock an additional 140+ New genetic health areas.

Each additional area focuses on a specific topic to provide results and recommendations according to your health goal or interest, allowing you to unlock your DNA's potential, and start your journey for health you.

DNA Timeline (DNA+ Epigenetics Test)_‍
Has all the key benefits from our Core DNA Test, but then through the new and exciting world of Epigenetics, allows you to discover your biological age and “True real time methylation patterns” to understand the effects of cellular ageing.

Step 2: Complete your test and access your personlized muhdohub Score app

Complete your easy at-home test and instantly access your muhdohub score app. Discover key health insights and take control of your wellness.

The muhdohub Score utilises a 15-question survey which integrates your responses with an extensive database of gene expression levels derived from DNA methylation research, as well as the latest peer reviewed scientific publications.

By analysing key biological markers, we aim to help you better understand how your body is functioning at a molecular level and identify areas where you can optimise your health

Step 3: Tailor your supplement regimen to your unique DNA profile

Use your detailed epigenetic insights to customize your supplement plan with premium booster formulas backed by real science.

Unlocking the secrets to longevity, will always start with the basics and the nutrients you’ve forgotten. These supplements also provide what we consider the most important nutrients, and fundamental for everyone to improve all aspects of their Health and Longevity.

Timeless
Vitamin D
Tri-Magnesium
B- Vit Complex
Omega 3
Selenium +

Download the app to understand your health

Start your DNA and personalised health journey now with the muhdohub app.
‍
Unlock tailored and unique Nutri-genetic insights which combine both your DNA with lifestyle data to hyper personalise your nutrition and health information.

Coming Soon to App store and Google Play

Coming Soon

AI health Coach

A personalized guide to understanding your results and achieving a healthier, more vibrant life.

Biological Age

Discover your biological age and ways to improve it

Brain Training

Train your mind, track progress, unlock potential.

AR Results

See your results in augmented reality and understand their impack on your body.

AI health Coach

A personalized guide to understanding your results and achieving a healthier, more vibrant life.

Biological Age

Discover your biological age and ways to improve it.

Brain Traning

Tran your mind, track progress, unlock potential

Brain Traning

Tran your mind, track progress, unlock potential

Introduction to Cellixa

The Cellixa supplement range focuses on the vitamins, minerals and other essential nutrients which are in many ways the forgotten foundations and building blocks for our health.

In the new era of health and longevity supplements, certain companies and manufactures in their quest, and in the race to appear unique have forgotten about the basic building blocks of human biology.

"As unlocking the secrets to longevity will always start with the basics"

Vitamins and minerals are essential nutrients which serve as the foundation for human health. They play critical roles in almost every biological process, from energy production and Immune Function to Cellular Repair and DNA Synthesis.

Cellixa's range of Health and Longevity supplements were also exclusively developed with the help of Nutrigenetics experts at muhdohub.

muhdohub, is a pioneer of British and Longevity Science with expertise in Epigenetics and Personalised Health.

Their vast experience and knowledge in analysing Genetic and Epigenetic data provided and foundation for formulating a range of Cellixa products tailored to enhance health-span and combat the effects of ageing.

Their team of nutritionists, biochemists, and product developers ensured Cellixa was grounded in Scientific research and evidence.

Muhdo's extensive database of DNA and Epigenetic results from over 70,000 customers, helped identify key nutrients and compounds that influence Gene Expression and improve Biological Ageing.

Who are muhdohub?

The fantasy of living forever has endured for centuries, from the fountain of youth to gaining immortality from a magic spell. However, the gap between life and health expectancy is growing larger every year.

We might be living longer, but unfortunately not healthier. Increased cases or long-term conditions like asthma, diabetes, obesity and heart disease are sadly on the rise.

muhdohub is a data-driven personalised and a preventative health and wellness ecosystem that integrates epigenetics, genetics, health, fitness, nutrition, cognitive testing, facial tracking and wellbeing into an app-based platform.

Muhdo’s bioinformatics and science team has identified genes, biomarkers and environmental factors that correlate to external and cellular ageing.

It is estimated that as much as 70 per cent of our health outcomes relates to epigenetics/gene expression which is the most important factor affecting our health — from ageing and immunity, to even how we feel.

muhdohub collects objective genetic, epigenetic, health and time stamped lifestyle data to help individuals reduce the risk of future adverse health issues by providing them with the tools and knowledge to live healthier lifestyles - all underpinned by peer reviewed research.

Partnerships formed better product backed by science

muhdohub is the science arm for muhdohub which has established itself as a leader in personalised genetic health solutions through its collaborations with various illustrious science and research partners. These partnerships enhance the company’s ability to deliver cutting-edge research driven insights into genetic and epigenetic health.

muhdohub during the past 8 years has collaborated, engaged & partnered with a diverse collection of established Universities, Organisations and other Institutions globally such as Kings College London, The National University of Singapore and the European Union.

The partnership with the European Union's Predictom Project represents a significant collaboration aimed at advancing scientific innovation and Epigenetic research into Alzheimer's.

Our Partnership

NHS

The National Health Service (NHS) is the umbrella term for the publicly funded healthcare systems of the United Kingdom, comprising the NHS in England, NHS Scotland and NHS Wales.

Read Full Article

Predictom

The partnership with the European Union's Predictom Project represents a significant collaboration aimed at advancing scientific innovation and Epigenetic research into Alzheimer’s. PREDICTOM project secures EUR 21 million investment to pioneer early Alzheimer's detection.

Read Full Article

King's College London

Muhdo Partner With King's College London to Undertake an Advanced Research Project Around Epigenetics, AI and Informatics.

Read Full Article

National University of Singapore

Muhdo Partner With NUS in advanced longevity research.

Read Full Article

New Scientist

Epigenetic testing firms claim to help you live a healthier lifestyle.

Read Full Article

Forbes

The Future Of Health And Fitness:
Personalization And Genetic Insight Through DNA Testing

Read Full Article

The Telegraph

What is an epigenetic wellness regime?

Read Full Article

Nutra Ingredients Europe

"The future is here": AI tool develops scientifically-sound supplements at speed.

Read Full Article

Illumina

Additionally, Muhdo has partnered with Illumina, a global leader in DNA sequencing technology, to ensure the precision and reliability of its genetic and epigenetic analyses.

Read Full Article

Through these collaborations, muhdohub remains at the forefront of innovation,
ensuring its users benefit from scientifically validated and
actionable health insights.

Blood Nutrient Deficiency vs DNA Nutrient Inefficiency

The distinction between a nutrient deficiency identified through a blood Test and a DNA nutrient inefficiency (Saliva Test) lies in their origins, implications, and how they affect your health.

Blood Test Nutrient Deficiency

A nutrient deficiency measured through a blood test reflects your current nutrient status and the actual levels of vitamins, minerals, or other nutrients circulating in your blood. This can result from:

Poor dietary intake.
Malabsorption issue (e.g., gut disorders like celiac disease)
Increased nutrient needs due to stress, illness, or pregnancy
Rapid depletion due to chronic conditions or infections

Example: A blood test might reveal low vitamin D levels due to limited sun exposure, insufficient dietary or supplement intake. This deficiency directly affects bodily functions, such as bone health and immune function.

Key Features:

Immediate snapshots of your current nutrient levels.
Reflects short-term imbalances.
Can be corrected through supplementation or dietary changes.

DNA Nutrient Inefficiency

A DNA nutrient inefficiency is a genetic predisposition that affects how your body metabolises, absorbs, or utilises specific nutrients.

It does not measure nutrients levels at that present time but highlights inherited traits that may make it harder to obtain health from your diet and/or a supplement, which might lead to inefficiencies or increased nutrient requirements.

Example: A person with a variation in the MTHFR gene may have reduced ability to utilise vitamin B12, which is crucial for DNA repair and methylation. Even with normal B12 intake, this inefficiency can result in functional deficiencies over time.

Key features:

Reflect long-term genetic tendencies, not immediate status.
Helps identify risks of nutrient imbalances before they manifest.
Requires personalised interventions (e.g., Methylation supplementation for MTHFR variants).

Comparison

Nutrient Deficiency (Blood)

DNA Nutrient Inefficiency

Poor intake, absorption, or demand

Cause

Genetic variations affecting nutrient use

Current, short-term status

Timeframe

Long-term predisposition

Blood test (e.g. Serum levels)

Measurement

DNA test (gene-specific analysis)

Immediate supplementation or diet

Correction

Targeted interventions tailored to genetics

Low vitamin B12 in blood

Example

MTHFR variant affecting B12 metabolism

Direct and immediate on health

Impact

Potential risk if not addressed over time

What's the difference between genetics and epigenetics?

Genetics refers to the DNA you inherit from your parents which is fixed and does not change. While your genetic code remains the same throughout your life, environmental factors like diet, exercise, stress, and toxins can influence how genes are expressed (turned on or off) through epigenetic modifications such as DNA methylation.

Can my lifestyle influence my genes?

Yes! While your DNA sequence (the genetic code you inherit from your parents) remains the same throughout your life, your lifestyles choices can influence how your genes are expressed, this is known as epigenetics.

Epigenetics mechanisms, such as DNA methylation, act like switches that turn genes "on" or "off" based on environmental and lifestyle factors. This means that your diet, exercise, sleep, stress levels, and exposure to toxins can all affect how your genes function, potentially affecting your health, ageing, and disease risk.

What is Methylation?

DNA methylation is an epigenetics and crucial biological process that happens billions of times per second in nearly every cell in your body where chemical groups (methyl groups) attach to your DNA, affecting how your genes are turned on or off without altering the DNA sequence itself.

This plays a vital role in many essential functions, including DNA repair, gene expression, detoxification, and energy production.

Why is Methylation Important?

Methylation acts like a switch or dimmer, turning genes on or off or adjusting their activity levels. For example, it helps regulate how genes respond to stress, how hormones are balanced, and how toxins are processed and removed from the body.

It also supports brain health, heart function, and immune system activity. Proper methylation is essential for maintaining overall health and well-being.

What nutrients affect Methylation?

Methylation relies on specific nutrients, often called "methyl donors," to work efficiently. Key nutrients include B vitamins (B6, B9, and B12), choline, and betaine. These nutrients help your body generate and replenish methyl groups.

Without adequate amounts of these nutrients, the methylation process can slow down or become less effective, potentially leading to a higher risk of health problems, including fatigue, immune dysfunction, and even chronic diseases.

What is the best diet to improve Methylation?

A diet rich in leafy greens (for folate or B9), fish and eggs (for B12 and choline), or nuts (for B6) can help ensure that your methylation process runs smoothly.

Avoiding nutrient deficiencies is crucial because inefficient methylation can affect everything from DNA stability to mental health. By eating a nutrient-dense diet or using certain supplements as needed, you can support healthy methylation and promote long-term health.